| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM50080557 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1475201 (CHEMBL3424956) |
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| IC50 | 30140±n/a nM |
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| Citation |  Stefek, M; Soltesova Prnova, M; Majekova, M; Rechlin, C; Heine, A; Klebe, G Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold. J Med Chem58:2649-57 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35797.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1512484 |
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| Residue: | 316 |
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| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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| BDBM50080557 |
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| n/a |
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| Name | BDBM50080557 |
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| Synonyms: | CHEMBL3422321 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20N2O2 |
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| Mol. Mass. | 260.3315 |
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| SMILES | CCN(CC)Cc1cn(CC(O)=O)c2ccccc12 |
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| Structure | 
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