| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycine receptor subunit alpha-1 |
|---|
| Ligand | BDBM50048280 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1474520 (CHEMBL3423809) |
|---|
| EC50 | 1300±n/a nM |
|---|
| Citation |  Wells, MM; Tillman, TS; Mowrey, DD; Sun, T; Xu, Y; Tang, P Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptora1 for the treatment of pain. J Med Chem58:2958-66 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glycine receptor subunit alpha-1 |
|---|
| Name: | Glycine receptor subunit alpha-1 |
|---|
| Synonyms: | GLRA1 | GLRA1_HUMAN | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 52635.39 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23415 |
|---|
| Residue: | 457 |
|---|
| Sequence: | MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA
KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
|
|
|
|---|
| BDBM50048280 |
|---|
| n/a |
|---|
| Name | BDBM50048280 |
|---|
| Synonyms: | 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid | 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid | ADAPALENE | CHEMBL1265 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H28O3 |
|---|
| Mol. Mass. | 412.5201 |
|---|
| SMILES | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O |TLB:7:8:11:15.14.13,THB:9:10:13:17.8.16,9:8:11.10.15:13,16:8:11:15.14.13,16:14:11:17.9.8| |
|---|
| Structure | 
|
|---|
Search and Browse
