| Reaction Details |
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 | Report a problem with these data |
| Target | Glycine receptor subunit alpha-1 |
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| Ligand | BDBM50022889 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1474520 (CHEMBL3423809) |
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| EC50 | 2500±n/a nM |
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| Citation |  Wells, MM; Tillman, TS; Mowrey, DD; Sun, T; Xu, Y; Tang, P Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptora1 for the treatment of pain. J Med Chem58:2958-66 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycine receptor subunit alpha-1 |
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| Name: | Glycine receptor subunit alpha-1 |
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| Synonyms: | GLRA1 | GLRA1_HUMAN | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52635.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23415 |
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| Residue: | 457 |
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| Sequence: | MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA
KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
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| BDBM50022889 |
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| n/a |
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| Name | BDBM50022889 |
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| Synonyms: | (2,8-Bis-trifluoromethyl-quinolin-4-yl)-(1-methyl-piperidin-2-yl)-methanol | (2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol | (2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol( Mefloquine) | (2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol; (Mefloquine or MF) | (2,8-bis(trifluoromethyl)quinolin-4-yl)(piperidin-2-yl)methanol | (S)-(2,8-Bis-trifluoromethyl-quinolin-4-yl)-(R)-piperidin-2-yl-methanol | (S)-(2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol | (S)-(2,8-bis(trifluoromethyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol | 2,8-di(trifluoromethyl)-4-quinolyl-hexahydro-2-pyridinylmethanol(Mefloquine) | 2-[(2,8-Bis-trifluoromethyl-quinolin-4-yl)-hydroxy-methyl]-piperidinium | CHEMBL416956 | GNF-Pf-5544 | Lariam | MEFLOQUINE | [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol | med.21724, Compound Mefloquine | melfoquine | rac-mefloquine | rel-(2,8-bis(trifluoromethyl)quinolin-4-yl)(piperidin-2-yl)methanol |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16F6N2O |
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| Mol. Mass. | 378.3122 |
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| SMILES | OC(C1CCCCN1)c1cc(nc2c(cccc12)C(F)(F)F)C(F)(F)F |
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| Structure | 
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