| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
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| Ligand | BDBM50204589 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1477871 (CHEMBL3429150) |
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| IC50 | 122±n/a nM |
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| Citation |  Lawrence, HR; Mahajan, K; Luo, Y; Zhang, D; Tindall, N; Huseyin, M; Gevariya, H; Kazi, S; Ozcan, S; Mahajan, NP; Lawrence, NJ Development of novel ACK1/TNK2 inhibitors using a fragment-based approach. J Med Chem58:2746-63 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lck |
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| Name: | Tyrosine-protein kinase Lck |
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| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
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| Type: | n/a |
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| Mol. Mass.: | 57987.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06239 |
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| Residue: | 509 |
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| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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| BDBM50204589 |
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| n/a |
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| Name | BDBM50204589 |
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| Synonyms: | (S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine | CHEMBL247070 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N3O2 |
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| Mol. Mass. | 371.4317 |
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| SMILES | C(Nc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1)[C@@H]1CCCO1 |
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| Structure | 
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