Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSodium/nucleoside cotransporter 2
LigandBDBM50085467
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1477251 (CHEMBL3428943)
IC50>100000±n/a nM
Citation Tatani, KHiratochi, MNonaka, YIsaji, MShuto, S Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett6:244-8 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium/nucleoside cotransporter 2
Name:Sodium/nucleoside cotransporter 2
Synonyms:CNT2 | S28A2_HUMAN | SLC28A2
Type:PROTEIN
Mol. Mass.:71934.06
Organism:Homo sapiens (Human)
Description:ChEMBL_1477251
Residue:658
Sequence:
MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSR
WPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVH
SFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGI
CMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYT
VAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTA
TETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDAS
SLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLA
TNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMV
AEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLS
SIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPN
TSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50085467
n/a
NameBDBM50085467
Synonyms:CHEMBL3427694
TypeSmall organic molecule
Emp. Form.C18H19N5O5
Mol. Mass.385.374
SMILESNc1ncnc2n(cnc12)[C@@H]1O[C@H](COC(=O)Cc2ccccc2)[C@@H](O)[C@H]1O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: