Ki Summary

Reaction Details

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Target

Sodium/nucleoside cotransporter 2

Ligand

BDBM20875

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1477251 (CHEMBL3428943)

IC50

>1000000±n/a nM

Citation

Tatani, K; Hiratochi, M; Nonaka, Y; Isaji, M; Shuto, S Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett6:244-8 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sodium/nucleoside cotransporter 2

Name:

Sodium/nucleoside cotransporter 2

Synonyms:

CNT2 | S28A2_HUMAN | SLC28A2

Type:

PROTEIN

Mol. Mass.:

71934.06

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1477251

Residue:

658

Sequence:

MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSR
WPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVH
SFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGI
CMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYT
VAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTA
TETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDAS
SLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLA
TNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMV
AEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLS
SIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPN
TSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA

BDBM20875

n/a

Name

BDBM20875

Synonyms:

1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3-(4-hydroxyphenyl)propan-1-one | CHEMBL241384 | CHEMBL245067 | JMC511145 Compound 1 | O-glucoside, 1 | Phlorizin

Type

Natural product

Emp. Form.

C21H24O10

Mol. Mass.

436.4093

SMILES

OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O

Structure