Reaction Details |
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Target | Heat shock protein 75 kDa, mitochondrial |
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Ligand | BDBM50087452 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1478164 (CHEMBL3427925) |
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IC50 | 3600±n/a nM |
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Citation | Patel, HJ; Patel, PD; Ochiana, SO; Yan, P; Sun, W; Patel, MR; Shah, SK; Tramentozzi, E; Brooks, J; Bolaender, A; Shrestha, L; Stephani, R; Finotti, P; Leifer, C; Li, Z; Gewirth, DT; Taldone, T; Chiosis, G Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem58:3922-43 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heat shock protein 75 kDa, mitochondrial |
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Name: | Heat shock protein 75 kDa, mitochondrial |
Synonyms: | HSP75 | TRAP1 | TRAP1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 80120.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1478164 |
Residue: | 704 |
Sequence: | MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLGPRRNPAWSLQAGRLFS
TQTAEDKEEPLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNA
SDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGS
KAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFE
IAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWM
MDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRELG
SSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQ
RLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQL
TSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHLR
EFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVT
LRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRAS
EPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKALERH
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BDBM50087452 |
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n/a |
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Name | BDBM50087452 |
Synonyms: | CHEMBL3426739 |
Type | Small organic molecule |
Emp. Form. | C16H12Cl3N5S |
Mol. Mass. | 412.724 |
SMILES | Nc1ncnc2n(CCCC#C)c(Sc3ccc(Cl)c(Cl)c3Cl)nc12 |
Structure |
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