| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily D member 3 |
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| Ligand | BDBM50061306 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1478653 (CHEMBL3430554) |
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| IC50 | 5011872±n/a nM |
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| Citation |  Mirams, GR; Davies, MR; Brough, SJ; Bridgland-Taylor, MH; Cui, Y; Gavaghan, DJ; Abi-Gerges, N Prediction of Thorough QT study results using action potential simulations based on ion channel screens. J Pharmacol Toxicol Methods70:246-54 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily D member 3 |
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| Name: | Potassium voltage-gated channel subfamily D member 3 |
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| Synonyms: | KCND3 | KCND3_HUMAN | Kv channel-interacting protein 2/Potassium voltage-gated channel subfamily D member 3 | Potassium voltage-gated channel subfamily D member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv4.3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73464.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1478652 |
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| Residue: | 655 |
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| Sequence: | MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLER
YPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF
YGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTST
LALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVE
YLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKF
SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWY
TIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRR
AQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLL
HCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHP
GLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDG
LRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL
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| BDBM50061306 |
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| n/a |
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| Name | BDBM50061306 |
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| Synonyms: | (3S,4aS,8aS)-2-[(2R,3R)-2-Hydroxy-3-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide; compound with methanesulfonic acid | AG-1343 | CHEMBL1205 | NELFINAVIR MESYLATE | Nelfinavir | Viracept | cmdc.202100576, 24h |
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| Type | Small organic molecule |
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| Emp. Form. | C32H45N3O4S |
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| Mol. Mass. | 567.782 |
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| SMILES | Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C |r| |
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| Structure | 
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