Reaction Details |
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Target | UDP-glucuronosyltransferase 1A1 |
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Ligand | BDBM50062551 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1492023 (CHEMBL3529515) |
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IC50 | >100000±n/a nM |
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Citation | Reese, MJ; Savina, PM; Generaux, GT; Tracey, H; Humphreys, JE; Kanaoka, E; Webster, LO; Harmon, KA; Clarke, JD; Polli, JW In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor. Drug Metab Dispos41:353-61 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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UDP-glucuronosyltransferase 1A1 |
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Name: | UDP-glucuronosyltransferase 1A1 |
Synonyms: | Bilirubin-specific UDPGT isozyme 1 | GNT1 | UD11_HUMAN | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UDP-glucuronosyltransferase 1A1 | UDPGT 1-1 | UGT-1A | UGT1 | UGT1*1 | UGT1-01 | UGT1.1 | UGT1A | UGT1A1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1 | hUG-BR1 |
Type: | Enzyme |
Mol. Mass.: | 59604.34 |
Organism: | Homo sapiens (Human) |
Description: | P22309 |
Residue: | 533 |
Sequence: | MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
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BDBM50062551 |
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n/a |
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Name | BDBM50062551 |
Synonyms: | CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572 |
Type | Small organic molecule |
Emp. Form. | C20H19F2N3O5 |
Mol. Mass. | 419.3788 |
SMILES | [H][C@]12Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N1[C@H](C)CCO2 |r| |
Structure |
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