| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group I member 2 |
|---|
| Ligand | BDBM50103617 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1487572 (CHEMBL3531878) |
|---|
| EC50 | 15800±n/a nM |
|---|
| Citation |  Shukla, SJ; Sakamuru, S; Huang, R; Moeller, TA; Shinn, P; Vanleer, D; Auld, DS; Austin, CP; Xia, M Identification of clinically used drugs that activate pregnane X receptors. Drug Metab Dispos39:151-9 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor subfamily 1 group I member 2 |
|---|
| Name: | Nuclear receptor subfamily 1 group I member 2 |
|---|
| Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 |
|---|
| Type: | Nuclear receptor |
|---|
| Mol. Mass.: | 49774.77 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75469 |
|---|
| Residue: | 434 |
|---|
| Sequence: | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
|
|
|
|---|
| BDBM50103617 |
|---|
| n/a |
|---|
| Name | BDBM50103617 |
|---|
| Synonyms: | CHEMBL451483 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C52H76O24 |
|---|
| Mol. Mass. | 1085.1454 |
|---|
| SMILES | [H][C@@]1(C[C@@H](O)[C@H](O)[C@@H](C)O1)O[C@@H]1C[C@H](Oc2cc3cc4C[C@@]([H])([C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@]([H])(O[C@H]5C[C@@H](O[C@@]6([H])C[C@@H](O[C@@]7([H])C[C@](C)(O)[C@H](O)[C@@H](C)O7)[C@H](O)[C@@H](C)O6)[C@H](O)[C@@H](C)O5)C(=O)c4c(O)c3c(O)c2C)O[C@H](C)[C@H]1O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
