| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-glucuronosyltransferase 1A4 |
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| Ligand | BDBM10015 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1487589 (CHEMBL3531895) |
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| IC50 | 4720±n/a nM |
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| Citation |  Edavana, VK; Dhakal, IB; Williams, S; Penney, R; Boysen, G; Yao-Borengasser, A; Kadlubar, S Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics. Drug Metab Dispos41:870-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-glucuronosyltransferase 1A4 |
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| Name: | UDP-glucuronosyltransferase 1A4 |
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| Synonyms: | Bilirubin-specific UDPGT isozyme 2 | GNT1 | GNT1 | UD14_HUMAN | UDP-glucuronosyltransferase 1-4 | UDP-glucuronosyltransferase 1-D | UDP-glucuronosyltransferase 1A4 | UDPGT 1-4 | UGT-1D | UGT1 | UGT1*4 | UGT1-04 | UGT1.4 | UGT1A4 | UGT1D | Uridine-5'-diphosphoglucuronosyltransferase 1A4 | hUG-BR2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 60042.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22310 |
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| Residue: | 534 |
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| Sequence: | MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
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| BDBM10015 |
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| n/a |
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| Name | BDBM10015 |
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| Synonyms: | 2-[3-(1-cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile | 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methyl-propanenitrile | ANASTROZOLE | CHEMBL1399 | NSC719344 | arimidex |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19N5 |
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| Mol. Mass. | 293.3663 |
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| SMILES | CC(C)(C#N)c1cc(Cn2cncn2)cc(c1)C(C)(C)C#N |
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| Structure | 
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