| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier organic anion transporter family member 2B1 |
|---|
| Ligand | BDBM50248106 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1490913 (CHEMBL3533583) |
|---|
| Ki | 8480±n/a nM |
|---|
| Citation |  Takeuchi, K; Sugiura, T; Umeda, S; Matsubara, K; Horikawa, M; Nakamichi, N; Silver, DL; Ishiwata, N; Kato, Y Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent. Drug Metab Dispos39:1088-96 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Solute carrier organic anion transporter family member 2B1 |
|---|
| Name: | Solute carrier organic anion transporter family member 2B1 |
|---|
| Synonyms: | KIAA0880 | OATP-B | OATP-RP2 | OATP2B1 | OATPB | OATPRP2 | Organic anion transporter B | Organic anion transporter polypeptide-related protein 2 | SLC21A9 | SLCO2B1 | SO2B1_HUMAN | Solute carrier family 21 member 9 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 76729.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1488531 |
|---|
| Residue: | 709 |
|---|
| Sequence: | MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASPDPQDVRPSVFHNIKLFVLCHSLLQL
AQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGY
GAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSNGNCSSY
TETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGL
AFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKE
MPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVF
PRVLLQTLRHPIFLLVVLSQVCLSSMAAGMAIFLPKFLERQFSITASYANLLIGCLSFPS
VIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITHQTSAH
PGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCS
CVVEGNPVLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVG
IQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRNRFIGLQFFFKT
GSVICFALVLAVLRQQDKEARTKESRSSPAVEQQLLVSGPGKKPEDSRV
|
|
|
|---|
| BDBM50248106 |
|---|
| n/a |
|---|
| Name | BDBM50248106 |
|---|
| Synonyms: | CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H22N4O4 |
|---|
| Mol. Mass. | 442.4666 |
|---|
| SMILES | Cc1[nH]n(-c2ccc(C)c(C)c2)c(=O)c1N=Nc1cccc(-c2cccc(c2)C(O)=O)c1O |w:16.18| |
|---|
| Structure | 
|
|---|
Search and Browse
