| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxanthine-guanine phosphoribosyltransferase |
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| Ligand | BDBM50089443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1496953 (CHEMBL3579427) |
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| Ki | 4000±n/a nM |
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| Citation |  Eng, WS; Hocková, D; ?pacek, P; Janeba, Z; West, NP; Woods, K; Naesens, LM; Keough, DT; Guddat, LW First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity. J Med Chem58:4822-38 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxanthine-guanine phosphoribosyltransferase |
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| Name: | Hypoxanthine-guanine phosphoribosyltransferase |
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| Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
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| Type: | Protein |
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| Mol. Mass.: | 24579.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00492 |
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| Residue: | 218 |
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| Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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| BDBM50089443 |
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| n/a |
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| Name | BDBM50089443 |
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| Synonyms: | CHEMBL3578109 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H20N4O9P2 |
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| Mol. Mass. | 426.2561 |
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| SMILES | OP(O)(=O)CCOCC(Cn1cnc2c1nc[nH]c2=O)OCCP(O)(O)=O |
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| Structure | 
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