Reaction Details |
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Target | Hypoxanthine-guanine phosphoribosyltransferase |
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Ligand | BDBM50089449 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1496953 (CHEMBL3579427) |
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Ki | 30±n/a nM |
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Citation | Eng, WS; Hocková, D; ?pacek, P; Janeba, Z; West, NP; Woods, K; Naesens, LM; Keough, DT; Guddat, LW First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity. J Med Chem58:4822-38 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hypoxanthine-guanine phosphoribosyltransferase |
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Name: | Hypoxanthine-guanine phosphoribosyltransferase |
Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
Type: | Protein |
Mol. Mass.: | 24579.61 |
Organism: | Homo sapiens (Human) |
Description: | P00492 |
Residue: | 218 |
Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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BDBM50089449 |
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n/a |
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Name | BDBM50089449 |
Synonyms: | CHEMBL3578114 |
Type | Small organic molecule |
Emp. Form. | C15H30N7O10P3 |
Mol. Mass. | 561.3609 |
SMILES | Nc1nc2n(CCN(CCN(CCP(O)(O)=O)CCP(O)(O)=O)CCP(O)(O)=O)cnc2c(=O)[nH]1 |
Structure |
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