Reaction Details |
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Target | Programmed cell death 1 ligand 1 |
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Ligand | BDBM50091329 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1497759 (CHEMBL3583018) |
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IC50 | 6±n/a nM |
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Citation | Abdel-Magid, AF Inhibitors of the PD-1/PD-L1 Pathway Can Mobilize the Immune System: An Innovative Potential Therapy for Cancer and Chronic Infections. ACS Med Chem Lett6:489-90 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Programmed cell death 1 ligand 1 |
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Name: | Programmed cell death 1 ligand 1 |
Synonyms: | B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1 |
Type: | PROTEIN |
Mol. Mass.: | 33278.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109807 |
Residue: | 290 |
Sequence: | MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
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BDBM50091329 |
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n/a |
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Name | BDBM50091329 |
Synonyms: | CHEMBL3582257 | US9872852, Example 196 |
Type | Small organic molecule |
Emp. Form. | C27H33NO6 |
Mol. Mass. | 467.554 |
SMILES | COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OC)c1CNC(CO)(CO)CO |
Structure |
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