| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Monocarboxylate transporter 1 |
|---|
| Ligand | BDBM50092065 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1498543 (CHEMBL3584796) |
|---|
| IC50 | 25±n/a nM |
|---|
| Citation |  Gurrapu, S; Jonnalagadda, SK; Alam, MA; Nelson, GL; Sneve, MG; Drewes, LR; Mereddy, VR Monocarboxylate transporter 1 inhibitors as potential anticancer agents. ACS Med Chem Lett6:558-61 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Monocarboxylate transporter 1 |
|---|
| Name: | Monocarboxylate transporter 1 |
|---|
| Synonyms: | MCT 1 | MOT1_RAT | Mct1 | Monocarboxylate transporter 1 | Monocarboxylate transporter 1 (MCT1) | Slc16a1 | Solute carrier family 16 member 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53245.17 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P53987 |
|---|
| Residue: | 494 |
|---|
| Sequence: | MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSW
ISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIG
GLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLI
LGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQ
TVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAF
VDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAF
GWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACG
VILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPL
QNSSGDPAEEESPV
|
|
|
|---|
| BDBM50092065 |
|---|
| n/a |
|---|
| Name | BDBM50092065 |
|---|
| Synonyms: | CHEMBL3582426 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H17N2NaO3 |
|---|
| Mol. Mass. | 308.3075 |
|---|
| SMILES | [Na+].COc1cc(ccc1\C=C(/C#N)C([O-])=O)N1CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
