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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 3 | ||
| Ligand | BDBM50092310 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1498186 (CHEMBL3583406) | ||
| Ki | 3.2±n/a nM | ||
| Citation |  Ran, X; Zhao, Y; Liu, L; Bai, L; Yang, CY; Zhou, B; Meagher, JL; Chinnaswamy, K; Stuckey, JA; Wang, S Structure-Based Design of¿-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. J Med Chem58:4927-39 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 3 | |||
| Name: | Bromodomain-containing protein 3 | ||
| Synonyms: | BRD3 | BRD3_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 3 | Bromodomain-containing protein 3 (BRD3) | KIAA0043 | RING3-like protein | RING3L | ||
| Type: | Protein | ||
| Mol. Mass.: | 79571.81 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15059 | ||
| Residue: | 726 | ||
| Sequence: |
| ||
| BDBM50092310 | |||
| n/a | |||
| Name | BDBM50092310 | ||
| Synonyms: | CHEMBL3581661 | US9675697, Cpd. No. 23 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23N5O2 | ||
| Mol. Mass. | 413.4717 | ||
| SMILES | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21 |(5.34,2.95,;5.34,1.67,;3.96,.87,;2.62,1.63,;1.3,.87,;1.3,-.64,;2.62,-1.4,;3.96,-.64,;5.34,-1.44,;5.49,-3.01,;4.53,-3.86,;7.04,-3.34,;7.84,-1.97,;6.77,-.78,;7.03,.46,;,-1.4,;-1.3,-.64,;-2.64,-1.4,;-3.92,-.64,;-3.92,.87,;-2.64,1.63,;-2.66,3.22,;-3.96,4.12,;-5.16,3.71,;-3.48,5.64,;-1.89,5.66,;-1.38,4.15,;.14,3.67,;1.21,2.62,;1.55,4.18,;-1.3,.87,)| | ||
| Structure | 
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