Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 2 | ||
| Ligand | BDBM50092341 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1498013 (CHEMBL3585074) | ||
| Ki | 15±n/a nM | ||
| Citation |  Ran, X; Zhao, Y; Liu, L; Bai, L; Yang, CY; Zhou, B; Meagher, JL; Chinnaswamy, K; Stuckey, JA; Wang, S Structure-Based Design of¿-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. J Med Chem58:4927-39 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 2 | |||
| Name: | Bromodomain-containing protein 2 | ||
| Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 88085.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P25440 | ||
| Residue: | 801 | ||
| Sequence: |
| ||
| BDBM50092341 | |||
| n/a | |||
| Name | BDBM50092341 | ||
| Synonyms: | CHEMBL3581660 | US9675697, Cpd. No. 22 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H25N5O2 | ||
| Mol. Mass. | 415.4876 | ||
| SMILES | CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 |(1.07,4.53,;.13,3.67,;-1.38,4.15,;-1.89,5.66,;-3.48,5.64,;-3.96,4.12,;-5.46,3.6,;-6.42,4.44,;-2.66,3.22,;-2.64,1.63,;-3.92,.87,;-3.92,-.64,;-2.64,-1.4,;-1.3,-.64,;,-1.4,;1.3,-.64,;2.62,-1.4,;3.96,-.64,;5.34,-1.44,;5.49,-3.01,;4.53,-3.86,;7.04,-3.34,;7.84,-1.97,;6.77,-.78,;7.03,.46,;3.96,.87,;5.34,1.67,;5.34,2.95,;2.62,1.63,;1.3,.87,;-1.3,.87,)| | ||
| Structure | 
| ||