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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Carbonic anhydrase 12 | ||
| Ligand | BDBM50092599 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1500874 (CHEMBL3588514) | ||
| Ki | 256±n/a nM | ||
| Citation |  Carradori, S; Mollica, A; Ceruso, M; D'Ascenzio, M; De Monte, C; Chimenti, P; Sabia, R; Akdemir, A; Supuran, CT New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies. Bioorg Med Chem23:2975-81 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Carbonic anhydrase 12 | |||
| Name: | Carbonic anhydrase 12 | ||
| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 39456.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Catalytic domain of human cloned isozyme was used in the assay | ||
| Residue: | 354 | ||
| Sequence: |
| ||
| BDBM50092599 | |||
| n/a | |||
| Name | BDBM50092599 | ||
| Synonyms: | CHEMBL3586213 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H32N2O3S | ||
| Mol. Mass. | 380.545 | ||
| SMILES | CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)NC1CCC(C)CC1 |(5.07,3.24,;4,3.86,;2.67,3.08,;1.33,3.85,;1.33,5.39,;2.67,6.16,;2.67,7.4,;,3.08,;-1.07,3.7,;-0,4.31,;,1.54,;1.33,.77,;1.33,-.77,;,-1.54,;-1.33,-.77,;-1.33,.77,;0,-3.08,;-1.06,-3.7,;1.34,-3.85,;1.34,-5.39,;2.68,-6.16,;2.68,-7.7,;1.34,-8.47,;1.34,-9.7,;.01,-7.7,;.01,-6.16,)| | ||
| Structure | 
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