| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP2 subtype |
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| Ligand | BDBM50092616 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1501401 (CHEMBL3588430) |
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| IC50 | 8.0±n/a nM |
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| Citation |  Fox, BM; Beck, HP; Roveto, PM; Kayser, F; Cheng, Q; Dou, H; Williamson, T; Treanor, J; Liu, H; Jin, L; Xu, G; Ma, J; Wang, S; Olson, SH A selective prostaglandin E2 receptor subtype 2 (EP2) antagonist increases the macrophage-mediated clearance of amyloid-beta plaques. J Med Chem58:5256-73 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP2 subtype |
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| Name: | Prostaglandin E2 receptor EP2 subtype |
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| Synonyms: | PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 39775.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43116 |
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| Residue: | 358 |
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| Sequence: | MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGR
RSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFS
LATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQ
YCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGS
GRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQA
LRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
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| BDBM50092616 |
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| n/a |
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| Name | BDBM50092616 |
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| Synonyms: | CHEMBL3586360 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19ClFN3O2 |
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| Mol. Mass. | 423.867 |
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| SMILES | Fc1ccc2n(ccc2c1)-c1cc(Cl)c2OCCN(Cc3cc[nH]c(=O)c3)Cc2c1 |
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| Structure | 
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