| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
|---|
| Ligand | BDBM50092820 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1500328 (CHEMBL3588639) |
|---|
| IC50 | 2200±n/a nM |
|---|
| Citation |  McElroy, WT; Tan, Z; Ho, G; Paliwal, S; Li, G; Seganish, WM; Tulshian, D; Tata, J; Fischmann, TO; Sondey, C; Bian, H; Bober, L; Jackson, J; Garlisi, CG; Devito, K; Fossetta, J; Lundell, D; Niu, X Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation. ACS Med Chem Lett6:677-82 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interleukin-1 receptor-associated kinase 4 |
|---|
| Name: | Interleukin-1 receptor-associated kinase 4 |
|---|
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51519.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NWZ3 |
|---|
| Residue: | 460 |
|---|
| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
|
|
|
|---|
| BDBM50092820 |
|---|
| n/a |
|---|
| Name | BDBM50092820 |
|---|
| Synonyms: | CHEMBL1439445 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14N6O |
|---|
| Mol. Mass. | 318.3327 |
|---|
| SMILES | Cc1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
