| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta |
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| Ligand | BDBM50064356 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1502326 (CHEMBL3591560) |
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| EC50 | 1000±n/a nM |
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| Citation |  Koura, M; Matsuda, T; Okuda, A; Watanabe, Y; Yamaguchi, Y; Kurobuchi, S; Matsumoto, Y; Shibuya, K Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptorß-selective agonists. Bioorg Med Chem Lett25:2668-74 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxysterols receptor LXR-beta |
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| Name: | Oxysterols receptor LXR-beta |
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| Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50978.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55055 |
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| Residue: | 460 |
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| Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM50064356 |
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| n/a |
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| Name | BDBM50064356 |
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| Synonyms: | CHEMBL3403708 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27F3N2O5 |
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| Mol. Mass. | 468.4661 |
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| SMILES | CCCc1c(OCCCCN2C(=O)N(C)C(C)(C)C2=O)ccc2c(cc(=O)oc12)C(F)(F)F |
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| Structure | 
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