Reaction Details |
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Target | Bromodomain-containing protein 2 |
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Ligand | BDBM50094912 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1502940 (CHEMBL3591777) |
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IC50 | >50000±n/a nM |
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Citation | Duffy, BC; Liu, S; Martin, GS; Wang, R; Hsia, MM; Zhao, H; Guo, C; Ellis, M; Quinn, JF; Kharenko, OA; Norek, K; Gesner, EM; Young, PR; McLure, KG; Wagner, GS; Lakshminarasimhan, D; White, A; Suto, RK; Hansen, HC; Kitchen, DB Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design. Bioorg Med Chem Lett25:2818-23 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bromodomain-containing protein 2 |
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Name: | Bromodomain-containing protein 2 |
Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3 |
Type: | Protein |
Mol. Mass.: | 88085.95 |
Organism: | Homo sapiens (Human) |
Description: | P25440 |
Residue: | 801 |
Sequence: | MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
SDSSSSSSSSSSSDTSDSDSG
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BDBM50094912 |
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n/a |
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Name | BDBM50094912 |
Synonyms: | CHEMBL3589477 |
Type | Small organic molecule |
Emp. Form. | C25H22N2O4 |
Mol. Mass. | 414.4532 |
SMILES | COc1ccc(\C=C(\C(=O)N2CC(=O)Nc3cc(OC)ccc23)c2ccccc2)cc1 |
Structure |
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