| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
|---|
| Ligand | BDBM50094951 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1502979 (CHEMBL3591913) |
|---|
| IC50 | 234±n/a nM |
|---|
| Citation |  Ibrahim, MA; Abou-Seri, SM; Hanna, MM; Abdalla, MM; El Sayed, NA Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Ka inhibitors. Eur J Med Chem99:1-13 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
|---|
| Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
|---|
| Synonyms: | PI3-kinase p110 subunit alpha | PI3-kinase p110-alpha subunit | PI3K | PIK3CA | PK3CA_BOVIN | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Phosphoinositide 3-Kinase (PI3K), alpha | PtdIns-3-kinase p110 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 124338.95 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_1502979 |
|---|
| Residue: | 1068 |
|---|
| Sequence: | MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
|
|
|
|---|
| BDBM50094951 |
|---|
| n/a |
|---|
| Name | BDBM50094951 |
|---|
| Synonyms: | CHEMBL3589320 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H27N5O2S |
|---|
| Mol. Mass. | 425.547 |
|---|
| SMILES | CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1cccc(OC)c1)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
