| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group D member 2 |
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| Ligand | BDBM50095836 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1502200 (CHEMBL3590985) |
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| IC50 | 17500±n/a nM |
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| Citation |  Torrente, E; Parodi, C; Ercolani, L; De Mei, C; Ferrari, A; Scarpelli, R; Grimaldi, B Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBß and Autophagy. J Med Chem58:5900-15 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 1 group D member 2 |
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| Name: | Nuclear receptor subfamily 1 group D member 2 |
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| Synonyms: | EAR-1R | NR1D2 | NR1D2_HUMAN | Orphan nuclear hormone receptor BD73 | Rev-erb-beta | V-erbA-related protein 1-related |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64639.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1502200 |
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| Residue: | 579 |
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| Sequence: | MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDL
ANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHAC
EGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIP
KREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKS
SSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDH
CGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPI
DGFSQNENKNSYLCNTGGRMHLVCPLSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFA
KRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG
DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLI
MKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP
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| BDBM50095836 |
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| n/a |
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| Name | BDBM50095836 |
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| Synonyms: | CHEMBL3590544 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32FN3O |
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| Mol. Mass. | 397.5288 |
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| SMILES | CN1CCN(Cc2cc(CNC3(CCCC3)c3ccccc3F)ccc2O)CC1 |
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| Structure | 
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