| Reaction Details |
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 | Report a problem with these data |
| Target | Alkaline phosphatase, placental type |
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| Ligand | BDBM50080274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1506090 (CHEMBL3595956) |
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| Ki | 580000±n/a nM |
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| Citation |  Fonseca, EM; Trivella, DB; Scorsato, V; Dias, MP; Bazzo, NL; Mandapati, KR; de Oliveira, FL; Ferreira-Halder, CV; Pilli, RA; Miranda, PC; Aparicio, R Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates. Bioorg Med Chem23:4462-71 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alkaline phosphatase, placental type |
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| Name: | Alkaline phosphatase, placental type |
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| Synonyms: | ALPP | Alkaline phosphatase placental type | PLAP | PPB1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57950.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1506090 |
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| Residue: | 535 |
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| Sequence: | MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLII
FLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATA
YLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAG
TYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYP
DDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEI
HRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAI
ERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPG
YVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFI
AHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
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| BDBM50080274 |
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| n/a |
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| Name | BDBM50080274 |
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| Synonyms: | Benzyl-phosphonic acid | CHEMBL299737 | Phenyl-methanephosphonic acid anion | benzylphosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C7H9O3P |
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| Mol. Mass. | 172.1183 |
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| SMILES | OP(O)(=O)Cc1ccccc1 |
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| Structure | 
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