Reaction Details |
| Report a problem with these data |
Target | NAD-dependent protein deacetylase sirtuin-2 |
---|
Ligand | BDBM50096901 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1499224 (CHEMBL3582613) |
---|
IC50 | 4700±n/a nM |
---|
Citation | Khanfar, MA; Quinti, L; Wang, H; Nobles, J; Kazantsev, AG; Silverman, RB Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors. ACS Med Chem Lett6:607-11 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
NAD-dependent protein deacetylase sirtuin-2 |
---|
Name: | NAD-dependent protein deacetylase sirtuin-2 |
Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
Type: | Hydrolase |
Mol. Mass.: | 43172.62 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 389 |
Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
|
|
|
BDBM50096901 |
---|
n/a |
---|
Name | BDBM50096901 |
Synonyms: | CHEMBL3580796 |
Type | Small organic molecule |
Emp. Form. | C20H14ClN3O3S |
Mol. Mass. | 411.861 |
SMILES | Clc1ccc(CS(=O)(=O)c2cccc(c2)C(=O)Nc2ccc(cn2)C#N)cc1 |
Structure |
|