| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin V |
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| Ligand | BDBM50099236 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1459716 (CHEMBL3370434) |
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| IC50 | 865±n/a nM |
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| Citation |  Sleebs, BE; Gazdik, M; O'Neill, MT; Rajasekaran, P; Lopaticki, S; Lackovic, K; Lowes, K; Smith, BJ; Cowman, AF; Boddey, JA Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax. J Med Chem57:7644-62 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin V |
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| Name: | Plasmepsin V |
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| Synonyms: | Plasmepsin V |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68485.65 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_109726 |
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| Residue: | 590 |
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| Sequence: | MNNYFLRKENFFILFCFVFVSIFFVSNVTIIKCNNVENKIDNVGKKIENVGKKIGDMENK
NDNVENKNDNVGNKNDNVKNASSDLYKYKLYGDIDEYAYYFLDIDIGKPSQRISLILDTG
SSSLSFPCNGCKDCGIHMEKPYNLNYSKTSSILYCNKSNCPYGLKCVGNKCEYLQSYCEG
SQIYGFYFSDIVTLPSYNNKNKISFEKLMGCHMHEESLFLHQQATGVLGFSLTKPNGVPT
FVDLLFKHTPSLKPIYSICVSEHGGELIIGGYEPDYFLSNQKEKQKMDKSDNNSSNKGNV
SIKLKNNDKNDDEENNSKDVIVSNNVEDIVWQAITRKYYYYIKIYGLDLYGTNIMDKKEL
DMLVDSGSTFTHIPENIYNQINYYLDILCIHDMTNIYEINKRLKLTNESLNKPLVYFEDF
KTALKNIIQNENLCIKIVDGVQCWKSLENLPNLYITLSNNYKMIWKPSSYLYKKESFWCK
GLEKQVNNKPILGLTFFKNKQVIFDLQQNQIAFIESKCPSNLTSSRPRTFNEYREKENIF
LKVSYINLYCLWLLLALTILLSLILYVRKMFYMDYFPLSDQNKSPIQEST
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| BDBM50099236 |
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| n/a |
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| Name | BDBM50099236 |
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| Synonyms: | CHEMBL3344153 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H45F3N8O8 |
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| Mol. Mass. | 642.6688 |
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| SMILES | OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)[C@@H](O)CC(=O)NCCCC(N)=O |r| |
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| Structure | 
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