| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 3A5 |
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| Ligand | BDBM50030448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1485684 (CHEMBL3540824) |
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| IC50 | 630±n/a nM |
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| Citation |  Amundsen, R; Åsberg, A; Ohm, IK; Christensen, H Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro. Drug Metab Dispos40:655-61 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 3A5 |
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| Name: | Cytochrome P450 3A5 |
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| Synonyms: | CP3A5_HUMAN | CYP3A5 | Cytochrome P450 3A5 | Cytochrome P450 3A5 (CYP3A5) |
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| Type: | Protein |
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| Mol. Mass.: | 57118.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20815 |
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| Residue: | 502 |
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| Sequence: | MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG
LLQPEKPIVLKVDSRDGTLSGE
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| BDBM50030448 |
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| n/a |
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| Name | BDBM50030448 |
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| Synonyms: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | CHEMBL269732 | TACROLIMUS |
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| Type | Small organic molecule |
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| Emp. Form. | C44H69NO12 |
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| Mol. Mass. | 804.0182 |
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| SMILES | CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC |r,t:45| |
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| Structure | 
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