| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
|---|
| Ligand | BDBM50105868 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1507781 (CHEMBL3598538) |
|---|
| IC50 | 250±n/a nM |
|---|
| Citation |  Pelcman, B; Sanin, A; Nilsson, P; Schaal, W; Olofsson, K; Krog-Jensen, C; Forsell, P; Hallberg, A; Larhed, M; Boesen, T; Kromann, H; Claesson, HE N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase. Bioorg Med Chem Lett25:3017-23 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyunsaturated fatty acid lipoxygenase ALOX15 |
|---|
| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
|---|
| Synonyms: | 15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 74804.05 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 662 |
|---|
| Sequence: | MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
|
|
|
|---|
| BDBM50105868 |
|---|
| n/a |
|---|
| Name | BDBM50105868 |
|---|
| Synonyms: | CHEMBL3597766 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22ClFN4O4 |
|---|
| Mol. Mass. | 424.854 |
|---|
| SMILES | CCOC(=O)CCCCCNC(=O)n1ccc(n1)C(=O)Nc1ccc(F)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
