| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosylhomocysteinase |
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| Ligand | BDBM50105899 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1507791 (CHEMBL3598548) |
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| IC50 | 70±n/a nM |
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| Citation |  Nakao, A; Suzuki, H; Ueno, H; Iwasaki, H; Setsuta, T; Kashima, A; Sunada, S Discovery and structural analyses of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs. Bioorg Med Chem23:4952-69 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosylhomocysteinase |
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| Name: | Adenosylhomocysteinase |
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| Synonyms: | AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47714.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1507791 |
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| Residue: | 432 |
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| Sequence: | MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVET
AVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYF
KDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINV
NDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI
ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIG
HFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSN
SFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMS
CDGPFKPDHYRY
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| BDBM50105899 |
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| n/a |
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| Name | BDBM50105899 |
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| Synonyms: | CHEMBL3597816 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H40Cl2N4O5 |
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| Mol. Mass. | 655.611 |
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| SMILES | CN(CCNC(=O)CN(CC(=O)N(C)C1Cc2ccccc2C1)c1cc(Cl)ccc1Oc1ccc(Cl)cc1)C(=O)OC(C)(C)C |
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| Structure | 
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