| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50105982 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1506251 (CHEMBL3599135) |
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| EC50 | 355±n/a nM |
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| Citation |  Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Discovery of novel pyrazole-containing benzamides as potent ROR¿ inverse agonists. Bioorg Med Chem Lett25:2985-90 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORG_MOUSE | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58133.31 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_103664 |
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| Residue: | 516 |
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| Sequence: | MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
CNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGS
GPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELG
EPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSR
EEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVL
VRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTA
LVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEK
LQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK
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| BDBM50105982 |
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| n/a |
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| Name | BDBM50105982 |
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| Synonyms: | CHEMBL3598053 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H32FN5O2 |
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| Mol. Mass. | 492.6029 |
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| SMILES | [2H]C([2H])([2H])N(C(=O)c1c(C)cccc1F)c1ccc(cc1N1CC2CC2C1)-c1cc(NC(C)=O)nn1C(C)C |
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| Structure | 
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