| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
|---|
| Ligand | BDBM50106003 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1506251 (CHEMBL3599135) |
|---|
| EC50 | 199±n/a nM |
|---|
| Citation |  Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Discovery of novel pyrazole-containing benzamides as potent ROR¿ inverse agonists. Bioorg Med Chem Lett25:2985-90 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor ROR-gamma |
|---|
| Name: | Nuclear receptor ROR-gamma |
|---|
| Synonyms: | Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORG_MOUSE | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58133.31 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_103664 |
|---|
| Residue: | 516 |
|---|
| Sequence: | MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
CNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGS
GPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELG
EPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSR
EEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVL
VRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTA
LVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEK
LQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK
|
|
|
|---|
| BDBM50106003 |
|---|
| n/a |
|---|
| Name | BDBM50106003 |
|---|
| Synonyms: | CHEMBL3598071 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H29ClFN5O2 |
|---|
| Mol. Mass. | 525.032 |
|---|
| SMILES | [2H]C([2H])([2H])N(C(=O)c1c(F)cccc1Cl)c1ccc(cc1N1CC2CC2C1)-c1cc(NC(C)=O)nn1C1CCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
