| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Urease |
|---|
| Ligand | BDBM50106612 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1508665 (CHEMBL3602820) |
|---|
| IC50 | 143600±n/a nM |
|---|
| Citation |  Taha, M; Ismail, NH; Khan, A; Shah, SA; Anwar, A; Halim, SA; Fatmi, MQ; Imran, S; Rahim, F; Khan, KM Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies. Bioorg Med Chem Lett25:3285-9 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Urease |
|---|
| Name: | Urease |
|---|
| Synonyms: | UREA_CANEN | Urea amidohydrolase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 90746.20 |
|---|
| Organism: | Canavalia ensiformis (Jack bean) (Horse bean) |
|---|
| Description: | P07374 |
|---|
| Residue: | 840 |
|---|
| Sequence: | MKLSPREVEKLGLHNAGYLAQKRLARGVRLNYTEAVALIASQIMEYARDGEKTVAQLMCL
GQHLLGRRQVLPAVPHLLNAVQVEATFPDGTKLVTVHDPISRENGELQEALFGSLLPVPS
LDKFAETKEDNRIPGEILCEDECLTLNIGRKAVILKVTSKGDRPIQVGSHYHFIEVNPYL
TFDRRKAYGMRLNIAAGTAVRFEPGDCKSVTLVSIEGNKVIRGGNAIADGPVNETNLEAA
MHAVRSKGFGHEEEKDASEGFTKEDPNCPFNTFIHRKEYANKYGPTTGDKIRLGDTNLLA
EIEKDYALYGDECVFGGGKVIRDGMGQSCGHPPAISLDTVITNAVIIDYTGIIKADIGIK
DGLIASIGKAGNPDIMNGVFSNMIIGANTEVIAGEGLIVTAGAIDCHVHYICPQLVYEAI
SSGITTLVGGGTGPAAGTRATTCTPSPTQMRLMLQSTDDLPLNFGFTGKGSSSKPDELHE
IIKAGAMGLKLHEDWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRT
IHTYHSEGAGGGHAPDIIKVCGIKNVLPSSTNPTRPLTSNTIDEHLDMLMVCHHLDREIP
EDLAFAHSRIRKKTIAAEDVLNDIGAISIISSDSQAMGRVGEVISRTWQTADKMKAQTGP
LKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPSFFGTKPEMV
IKGGMVAWADIGDPNASIPTPEPVKMRPMYGTLGKAGGALSIAFVSKAALDQRVNVLYGL
NKRVEAVSNVRKLTKLDMKLNDALPEITVDPESYTVKADGKLLCVSEATTVPLSRNYFLF
|
|
|
|---|
| BDBM50106612 |
|---|
| n/a |
|---|
| Name | BDBM50106612 |
|---|
| Synonyms: | CHEMBL3600644 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H18ClN3O3 |
|---|
| Mol. Mass. | 431.871 |
|---|
| SMILES | COc1ccc(\C=N\NC(=O)c2ccc(\C=C3\C(=O)Nc4ccc(Cl)cc34)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
