| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Heat shock protein HSP 90-beta |
|---|
| Ligand | BDBM50107729 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1509295 (CHEMBL3603023) |
|---|
| IC50 | 736±n/a nM |
|---|
| Citation |  Sun, J; Lin, C; Qin, X; Dong, X; Tu, Z; Tang, F; Chen, C; Zhang, J Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors. Bioorg Med Chem Lett25:3129-34 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Heat shock protein HSP 90-beta |
|---|
| Name: | Heat shock protein HSP 90-beta |
|---|
| Synonyms: | HS90B_HUMAN | HSP 84 | HSP 90 | HSP90AB1 | HSP90B | HSPC2 | HSPCB | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90) |
|---|
| Type: | Molecular Chaperone |
|---|
| Mol. Mass.: | 83229.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08238 |
|---|
| Residue: | 724 |
|---|
| Sequence: | MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD
|
|
|
|---|
| BDBM50107729 |
|---|
| n/a |
|---|
| Name | BDBM50107729 |
|---|
| Synonyms: | CHEMBL3600495 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H30N2O4 |
|---|
| Mol. Mass. | 446.5381 |
|---|
| SMILES | CCNC(=O)c1noc(c1C#Cc1ccc(cc1)C(C)(C)C)-c1cc(C(C)C)c(O)cc1O |
|---|
| Structure | 
|
|---|
Search and Browse
