| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Ligand | BDBM50109702 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1510006 (CHEMBL3608059) |
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| IC50 | 24000±n/a nM |
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| Citation |  Pelcman, B; Sanin, A; Nilsson, P; No, K; Schaal, W; Öhrman, S; Krog-Jensen, C; Forsell, P; Hallberg, A; Larhed, M; Boesen, T; Kromann, H; Vogensen, SB; Groth, T; Claesson, HE 3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1. Bioorg Med Chem Lett25:3024-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Synonyms: | 12-LOX | 12/15-lipoxygenase | 15-LOX | Alox12l | Alox15 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, leukocyte-type | Arachidonate omega-6 lipoxygenase | LOX15_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 75377.59 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1510006 |
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| Residue: | 663 |
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| Sequence: | MGVYRIRVSTGDSKYAGSNNEVYLWLVGQHGEASLGKLLRPCRDSEAEFKVDVSEYLGPL
LFVRVQKWHYLTDDAWFCNWISVKGPGDQGSEYMFPCYRWVQGRSILSLPEGTGCTVVED
SQGLFRKHREEELEERRSLYRWGNWKDGSILNVAAASISDLPVDQRFREDKRIEFEASQV
IGVMDTVVNFPINTVTCWKSLDDFNCVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPM
VLKRSTCLPARLVFPPGMEKLQAQLNKELQKGTLFEADFFLLDGIKANVILCSQQYLAAP
LVMLKLMPDGQLLPIAIQLELPKTGSTPPPIFTPSDPPMDWLLAKCWVRSSDLQLHELQA
HLLRGHLMAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKAMS
TGGGGHLDLLKQAGAFLTYCSLCPPDDLAERGLLDIETCFYAKDALRLWQIMNRYVVGMF
NLHYKTDKAVQDDYELQSWCREITDIGLQGAQDRGFPTSLQSRAQACYFITMCIFTCTAQ
HSSVHLGQLDWFYWVPNAPCTMRLPPPTTKEATMEKLMATLPNPNQSTLQINVVWLLGRR
QAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSMVENS
VAI
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| BDBM50109702 |
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| n/a |
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| Name | BDBM50109702 |
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| Synonyms: | CHEMBL3604174 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H6Cl2N4O |
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| Mol. Mass. | 257.076 |
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| SMILES | Clc1ccc(NC(=O)c2cn[nH]n2)c(Cl)c1 |
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| Structure | 
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