Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Glucocorticoid receptor | ||
Ligand | BDBM50110730 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1510389 (CHEMBL3607229) | ||
IC50 | 11±n/a nM | ||
Citation | Luz, JG; Carson, MW; Condon, B; Clawson, D; Pustilnik, A; Kohlman, DT; Barr, RJ; Bean, JS; Dill, MJ; Sindelar, DK; Maletic, M; Coghlan, MJ Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site. J Med Chem58:6607-18 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Glucocorticoid receptor | |||
Name: | Glucocorticoid receptor | ||
Synonyms: | GCR_RAT | Glucocorticoid | Glucocorticoid Receptor (GR) | Glucocorticoid receptor | Grl | Nr3c1 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 87556.83 | ||
Organism: | RAT | ||
Description: | Glucocorticoid 0 RAT::P06536 | ||
Residue: | 795 | ||
Sequence: |
| ||
BDBM50110730 | |||
n/a | |||
Name | BDBM50110730 | ||
Synonyms: | CHEMBL3605919 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H32FN3O3S | ||
Mol. Mass. | 509.635 | ||
SMILES | COc1cc(F)ccc1-c1c(CN(C)Cc2ccccc2)[nH]c2c(NS(C)(=O)=O)cc(cc12)C(C)C |(-1,4.66,;-.24,3.69,;1.29,3.91,;1.86,5.34,;3.38,5.55,;3.84,6.7,;4.33,4.34,;3.76,2.91,;2.23,2.7,;1.76,1.24,;2.66,.02,;4.2,.03,;4.98,-1.29,;4.37,-2.37,;6.52,-1.28,;7.3,-2.61,;8.84,-2.59,;9.62,-3.92,;8.87,-5.26,;7.33,-5.27,;6.54,-3.95,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-1.02,-3.09,;-2.35,-3.87,;-3.42,-3.26,;-2.35,-5.1,;-3.42,-4.49,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;.3,.77,;-3.72,1.53,;-3.72,2.76,;-4.78,.91,)| | ||
Structure |