| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 3 |
|---|
| Ligand | BDBM91713 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1510493 (CHEMBL3607519) |
|---|
| IC50 | 169±n/a nM |
|---|
| Citation |  Djigoué, GB; Kenmogne, LC; Roy, J; Maltais, R; Poirier, D Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17ß-hydroxysteroid dehydrogenase type 3. Bioorg Med Chem23:5433-51 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 17-beta-hydroxysteroid dehydrogenase type 3 |
|---|
| Name: | 17-beta-hydroxysteroid dehydrogenase type 3 |
|---|
| Synonyms: | DHB3_RAT | Edh17b3 | Hsd17b3 | Testosterone 17-beta-dehydrogenase 3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 34235.73 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1510493 |
|---|
| Residue: | 306 |
|---|
| Sequence: | MEQFLLSVGLLVCLVCLVKCVRFSRYLFLSFCKALPGSFLRSMGQWAVITGAGDGIGKAY
SFELARHGLNVVLISRTLEKLQVISEEIERTTGSRVKVVQADFTREDIYDHIEEQLKGLE
IGVLVNNVGMLPNLLPSHFLSTSGESQSVIHCNITSVVKMTQLVLKHMESRRRGLILNIS
SGVGVRPWPLYSLYSASKAFVCTFSKALNVEYRDKGIIIQVLTPYSVSTPMTKYLNTSRV
TKTADEFVKESLKYVTIGAETCGCLAHEILAIILNLIPSRIFYSSTTQRFLLKQFSDYLK
SNISNR
|
|
|
|---|
| BDBM91713 |
|---|
| n/a |
|---|
| Name | BDBM91713 |
|---|
| Synonyms: | Androst-4-en-3,17-dione, 2 | Androst-4-ene-3,17-dione (3) | Androstenedione |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H26O2 |
|---|
| Mol. Mass. | 286.4085 |
|---|
| SMILES | C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CCC2=O |t:8| |
|---|
| Structure | 
|
|---|
Search and Browse
