| Reaction Details |
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 | Report a problem with these data |
| Target | Amiloride-sensitive sodium channel subunit alpha |
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| Ligand | BDBM50112170 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1512947 (CHEMBL3609986) |
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| IC50 | 6.0±n/a nM |
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| Citation |  Blass, B Novel Pyrazine Amide Compounds. ACS Med Chem Lett6:729-31 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amiloride-sensitive sodium channel subunit alpha |
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| Name: | Amiloride-sensitive sodium channel subunit alpha |
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| Synonyms: | Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel subunit alpha | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNNA_MOUSE | Scnn1a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78903.70 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_109863 |
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| Residue: | 699 |
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| Sequence: | MLDHTRAPELNLDLDLDVSNSPKGSMKGNNFKEQDLCPPLPMQGLGKGDKREEQALGPEP
SEPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTF
GMMYWQFALLFEEYFSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITE
QTLFDLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDN
NPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPALEEE
ALGSFIFTCRFNQAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLR
TEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGD
CTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSW
GYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYT
INNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELI
FDLLVITLIMLLHRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQGT
TPPLALTAPPPAYATLGPSASPLDSAVPGSSACAPAMAL
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| BDBM50112170 |
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| n/a |
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| Name | BDBM50112170 |
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| Synonyms: | CHEMBL3608425 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H38ClF3N6O4 |
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| Mol. Mass. | 651.119 |
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| SMILES | [O-]C(=O)C(F)(F)F.COc1ccc(CCC[N+]2(CCCc3ccccc3)CCCC(C2)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |
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| Structure | 
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