| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA (8-3)-desaturase |
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| Ligand | BDBM50116702 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1513296 (CHEMBL3611102) |
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| IC50 | 15±n/a nM |
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| Citation |  Baugh, SD; Pabba, PK; Barbosa, J; Coulter, E; Desai, U; Gay, JP; Gopinathan, S; Han, Q; Hari, R; Kimball, SD; Nguyen, HV; Ni, CY; Powell, DR; Smith, A; Terranova, KM; Wilson, A; Yu, XC; Lombardo, VK Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome. Bioorg Med Chem Lett25:3836-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA (8-3)-desaturase |
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| Name: | Acyl-CoA (8-3)-desaturase |
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| Synonyms: | FADS1 | FADS1_HUMAN | FADSD5 | Fatty acid desaturase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51985.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1513296 |
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| Residue: | 444 |
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| Sequence: | MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVIS
HYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVE
RMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHD
FGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFA
LGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMI
TFYVRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQL
QATCNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLL
SAFADIIHSLKESGQLWLDAYLHQ
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| BDBM50116702 |
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| n/a |
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| Name | BDBM50116702 |
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| Synonyms: | CHEMBL3608697 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H12ClNO3 |
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| Mol. Mass. | 277.703 |
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| SMILES | COc1ccc(O)c(c1)C(=O)Nc1cccc(Cl)c1 |
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| Structure | 
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