Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50117205 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1514011 (CHEMBL3616197) |
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Ki | 4.2±n/a nM |
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Citation | Damont, A; Marguet, F; Puech, F; Dollé, F Synthesis and in vitro characterization of novel fluorinated derivatives of the TSPO 18 kDa ligand SSR180575. Eur J Med Chem101:736-45 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50117205 |
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n/a |
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Name | BDBM50117205 |
Synonyms: | CHEMBL3613370 |
Type | Small organic molecule |
Emp. Form. | C24H20ClFN4O2 |
Mol. Mass. | 450.893 |
SMILES | CN(C)C(=O)Cc1nn(-c2ccccc2)c(=O)c2n(CC#CCF)c3cc(Cl)ccc3c12 |
Structure |
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