| Reaction Details |
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 | Report a problem with these data |
| Target | Menin |
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| Ligand | BDBM152230 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1515211 (CHEMBL3614558) |
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| IC50 | 1200±n/a nM |
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| Citation |  Pollock, J; Borkin, D; Lund, G; Purohit, T; Dyguda-Kazimierowicz, E; Grembecka, J; Cierpicki, T Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J Med Chem58:7465-74 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Menin |
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| Name: | Menin |
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| Synonyms: | MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2 |
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| Type: | Protein |
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| Mol. Mass.: | 68022.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00255 |
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| Residue: | 610 |
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| Sequence: | MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSED
HAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV
CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLT
LYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEI
YKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGI
CKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRR
RGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAP
TASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTL
SFLKRQRKGL
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| BDBM152230 |
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| n/a |
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| Name | BDBM152230 |
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| Synonyms: | US8993552, 65 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H23N5S2 |
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| Mol. Mass. | 361.528 |
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| SMILES | CCc1cc2c(ncnc2s1)N1CCN(CC1)C1=NCC(C)(C)S1 |t:20| |
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| Structure | 
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