| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Melatonin receptor type 1A |
|---|
| Ligand | BDBM50117877 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1514065 (CHEMBL3614203) |
|---|
| EC50 | 2420±n/a nM |
|---|
| Citation |  Spadoni, G; Bedini, A; Lucarini, S; Mari, M; Caignard, DH; Boutin, JA; Delagrange, P; Lucini, V; Scaglione, F; Lodola, A; Zanardi, F; Pala, D; Mor, M; Rivara, S Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines. J Med Chem58:7512-25 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Melatonin receptor type 1A |
|---|
| Name: | Melatonin receptor type 1A |
|---|
| Synonyms: | MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 39392.94 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P48039 |
|---|
| Residue: | 350 |
|---|
| Sequence: | MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
|
|
|
|---|
| BDBM50117877 |
|---|
| n/a |
|---|
| Name | BDBM50117877 |
|---|
| Synonyms: | CHEMBL3612458 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H19N3O |
|---|
| Mol. Mass. | 233.3095 |
|---|
| SMILES | CCNC(=O)NCC1CCc2ccccc2N1 |
|---|
| Structure | 
|
|---|
Search and Browse
