| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Yes |
|---|
| Ligand | BDBM50119568 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1517135 (CHEMBL3619918) |
|---|
| Ki | 610±n/a nM |
|---|
| Citation |  Kwarcinski, FE; Steffey, ME; Fox, CC; Soellner, MB Discovery of Bivalent Kinase Inhibitors via Enzyme-Templated Fragment Elaboration. ACS Med Chem Lett6:898-901 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Yes |
|---|
| Name: | Tyrosine-protein kinase Yes |
|---|
| Synonyms: | Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 60801.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07947 |
|---|
| Residue: | 543 |
|---|
| Sequence: | MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
|
|
|
|---|
| BDBM50119568 |
|---|
| n/a |
|---|
| Name | BDBM50119568 |
|---|
| Synonyms: | CHEMBL3617738 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H36N8O3 |
|---|
| Mol. Mass. | 568.6693 |
|---|
| SMILES | O=C(CCCCCC(=O)N1CCC[C@@H]1c1ccco1)Nc1cccc(Nc2nccc(Nc3cc([nH]n3)C3CC3)n2)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
