| Reaction Details |
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 | Report a problem with these data |
| Target | Poly(A)-specific ribonuclease PARN |
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| Ligand | BDBM50119716 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1518115 (CHEMBL3619398) |
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| IC50 | 23900±n/a nM |
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| Citation |  Jadhav, GP; Kaur, I; Maryati, M; Airhihen, B; Fischer, PM; Winkler, GS Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1. Bioorg Med Chem Lett25:4219-24 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Poly(A)-specific ribonuclease PARN |
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| Name: | Poly(A)-specific ribonuclease PARN |
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| Synonyms: | DAN | PARN | PARN_HUMAN | Poly(A)-specific ribonuclease (PARN) | Polyadenylate-specific ribonuclease |
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| Type: | Enzyme |
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| Mol. Mass.: | 73446.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O95453 |
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| Residue: | 639 |
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| Sequence: | MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKH
SMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQG
FDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKF
IDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIV
ISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQF
YCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKV
ESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFN
KLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTS
AFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLN
PQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEP
LSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW
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| BDBM50119716 |
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| n/a |
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| Name | BDBM50119716 |
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| Synonyms: | CHEMBL3616525 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23N5O3 |
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| Mol. Mass. | 357.4069 |
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| SMILES | CN(C)CCCn1c2ncn(CCc3ccccc3)c2c(=O)n(O)c1=O |
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| Structure | 
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