| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM50120884 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1520596 (CHEMBL3625144) |
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| Ki | 6.3±n/a nM |
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| Citation |  Roecker, AJ; Mercer, SP; Bergman, JM; Gilbert, KF; Kuduk, SD; Harrell, CM; Garson, SL; Fox, SV; Gotter, AL; Tannenbaum, PL; Prueksaritanont, T; Cabalu, TD; Cui, D; Lemaire, W; Winrow, CJ; Renger, JJ; Coleman, PJ Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements. Bioorg Med Chem Lett25:4992-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM50120884 |
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| n/a |
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| Name | BDBM50120884 |
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| Synonyms: | CHEMBL3622333 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22F3N7O2 |
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| Mol. Mass. | 461.4403 |
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| SMILES | COc1nc(ncc1C(F)(F)F)N1CC[C@@H](C)N(CC1)C(=O)c1ccccc1-n1nccn1 |r| |
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| Structure | 
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