Ki Summary

Reaction Details

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Target

Solute carrier family 40 member 1

Ligand

BDBM50120959

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1520975 (CHEMBL3624279)

EC50

44±n/a nM

Citation

Chua, K; Fung, E; Micewicz, ED; Ganz, T; Nemeth, E; Ruchala, P Small cyclic agonists of iron regulatory hormone hepcidin. Bioorg Med Chem Lett25:4961-9 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Solute carrier family 40 member 1

Name:

Solute carrier family 40 member 1

Synonyms:

Type:

PROTEIN

Mol. Mass.:

62541.43

Organism:

Homo sapiens (Human)

Description:

ChEMBL_109560

Residue:

571

Sequence:

MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLL
TAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHEL
LTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRI
DQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLK
EEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWV
SYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAF
TWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITP
TKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLL
QENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFR
FAQNTLGNKLFACGPDAKEVRKENQANTSVV

BDBM50120959

n/a

Name

BDBM50120959

Synonyms:

CHEMBL3623073

Type

Small organic molecule

Emp. Form.

C86H128N18O12S3

Mol. Mass.

1702.245

SMILES

[H][C@@]12CCCN1C(=O)[C@@H](NC(=O)[C@H](CSCc1cccc(CSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)NCCCCCC(=O)N(CC(N)=O)CC(=O)NCCCCCCCCCCCCCCCC)c1)NC(C)=O)C(c1ccccc1)c1ccccc1 |r|

Structure