Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM21354 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1521956 (CHEMBL3626980) |
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Ki | 6.0±n/a nM |
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Citation | Karila, D; Freret, T; Bouet, V; Boulouard, M; Dallemagne, P; Rochais, C Therapeutic Potential of 5-HT6 Receptor Agonists. J Med Chem58:7901-12 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM21354 |
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n/a |
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Name | BDBM21354 |
Synonyms: | 2-{1-[(5-chlorothiophene-2-)sulfonyl]-1H-indol-3-yl}ethan-1-amine | thiophene sulfonyltryptamine, 11m |
Type | Small organic molecule |
Emp. Form. | C14H13ClN2O2S2 |
Mol. Mass. | 340.848 |
SMILES | NCCc1cn(c2ccccc12)S(=O)(=O)c1ccc(Cl)s1 |
Structure |
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