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TargetFlap endonuclease 1
LigandBDBM50121696
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1516648
IC50>100000±n/a nM
Citation Chapman TMGillen KJWallace CLee MTBakrania PKhurana PCoombs PJStennett LFox SBureau EABrownlees JMelton DWSaxty B Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett 25:4097-103 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Flap endonuclease 1
Name:Flap endonuclease 1
Synonyms:DNase IV | FEN-1 | FEN1 | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:PROTEIN
Mol. Mass.:42602.57
Organism:Homo sapiens (Human)
Description:ChEMBL_1517026
Residue:380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
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  Blast E-value cutoff:
BDBM50121696
n/a
NameBDBM50121696
Synonyms:CHEMBL3617001
TypeSmall organic molecule
Emp. Form.C15H14ClNO3
Mol. Mass.291.73
SMILESOc1ccc(CNC(=O)Cc2ccccc2Cl)cc1O
Structure
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