| Reaction Details |
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 | Report a problem with these data |
| Target | Flap endonuclease 1 |
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| Ligand | BDBM50157846 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1517026 (CHEMBL3619485) |
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| IC50 | 57±n/a nM |
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| Citation |  Chapman, TM; Wallace, C; Gillen, KJ; Bakrania, P; Khurana, P; Coombs, PJ; Fox, S; Bureau, EA; Brownlees, J; Melton, DW; Saxty, B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett25:4104-8 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Flap endonuclease 1 |
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| Name: | Flap endonuclease 1 |
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| Synonyms: | DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42602.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1517026 |
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| Residue: | 380 |
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| Sequence: | MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
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| BDBM50157846 |
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| n/a |
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| Name | BDBM50157846 |
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| Synonyms: | 3-Hydroxy-7-p-tolyl-1H-furo[3,2-d]pyrimidine-2,4-dione | CHEMBL182381 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H10N2O4 |
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| Mol. Mass. | 258.2295 |
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| SMILES | Cc1ccc(cc1)-c1coc2c1[nH]c(=O)n(O)c2=O |
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| Structure | 
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